Metabolic Stress Response
Gene co-expression module in Colorectal carcinoma
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module mixes several programs. SERP1 (stress-associated ER protein 1, stabilizes SERCA under ER stress), HIGD1A (hypoxia-inducible gene, mitochondrial complex IV assembly under stress), PGK1 (phosphoglycerate kinase, glycolysis/hypoxia-responsive), and ANXA4 (annexin A4, stress-responsive membrane protein) suggest a stress-metabolic response. AP3S1 (AP-3 adaptor for lysosomal targeting) and TPD52 (vesicle trafficking, overexpressed in CRC) connect to vesicle biology. CMPK1 (UMP-CMP kinase for nucleotide salvage) and PDLIM1 (PDZ-LIM cytoskeletal) are more peripheral. The overall signature resembles a mild hypoxia/metabolic stress response in epithelial cells, consistent with CRC microenvironment.
Genes
Most correlated modules
- Endosomal Vesicle Recycling · correlation 0.85
- ER Protein Processing · correlation 0.82
- Endolysosomal Autophagy · correlation 0.82
- Actin-Vesicle Coupling · correlation 0.81
- ER Protein Processing · correlation 0.81
- ER-Golgi Trafficking · correlation 0.79
- Clathrin-mediated Endocytosis · correlation 0.76
- Aerobic Glycolysis Warburg · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.