Mitotic Spindle
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include TUBA1C (alpha-tubulin isoform), TUBB (beta-tubulin, core member with 5.8x prolif_DC enrichment), CALM3 (calmodulin-3, calcium signaling/cell cycle), YWHAQ (14-3-3 theta, cell cycle checkpoint), ARPP19 (cAMP-regulated phosphoprotein, mitotic regulator — inhibits PP2A at mitosis), RHOC (Rho GTPase, cytoskeletal/migration), FDPS (farnesyl diphosphate synthase, mevalonate pathway), VDAC2 (mitochondrial outer membrane), HMGN3 (chromatin), NAP1L1 (nucleosome assembly), IRF2 (transcription factor). The strong tubulin signal (TUBA1C, TUBB) combined with ARPP19 (mitotic PP2A inhibitor), CALM3, YWHAQ, and NAP1L1 points to a mitotic/cell cycle program. TUBB is 5.8x enriched in prolif_DC. This module is best described as a mitotic spindle/cell cycle program in proliferating DCs. The neighbor context (M7 with EZH2, M49 with TOP1) supports a proliferation-linked neighborhood.
Genes
Most correlated modules
- Inflammatory Stress Response · correlation 0.89
- Actin Cytoskeleton Remodeling · correlation 0.84
- Chromatin Remodeling · correlation 0.79
- Cytokine Receptor Signaling · correlation 0.69
- Cytoskeletal Motor Activity · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.