Cytokine Receptor Signaling
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
IFNAR1 (interferon-alpha/beta receptor 1) is the clearest functional anchor — it mediates type I IFN signaling, a key DC program. IL4R (IL-4 receptor) and TNIP2 (TNFAIP3-interacting protein 2, negative regulator of NF-κB/TLR signaling) add cytokine receptor/signaling context. PLXND1 (plexin D1, semaphorin receptor for DC migration) and CAPRIN1 (stress granule/RNA regulation) are supporting members. The module is enriched in prolif_DC (7.7x) and cDC1 (6.0x), consistent with cDC1 identity and IFN responsiveness. Moderate coherence with many weak members suggests a mixed module, but the cytokine receptor theme (IFNAR1, IL4R) is the most coherent biological signal.
Genes
Most correlated modules
- Cytoskeletal Motor Activity · correlation 0.84
- Chromatin Remodeling · correlation 0.80
- Inflammatory Stress Response · correlation 0.80
- Actin Cytoskeleton Remodeling · correlation 0.76
- Proliferating DC Mixed · correlation 0.75
- Mitotic Spindle · correlation 0.69
- Myeloid Stress Response · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.