Chromatin Remodeling
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include TXNL1 (thioredoxin-like, proteasome-associated), RALY (RNA-binding protein), MBD2 (methyl-CpG binding domain, epigenetic), KPNB1 (importin beta-1, nuclear transport), SMARCA5 (SWI/SNF chromatin remodeling ATPase), PRPF40A (pre-mRNA splicing), VCP (AAA-ATPase, ubiquitin-proteasome/ER stress), PSMC1 (proteasome 19S ATPase), PSMD1 (proteasome 19S), SF3B2 (splicing factor), EZH2 (PRC2 histone methyltransferase, proliferation marker), HDAC2 (histone deacetylase), RIF1 (DNA repair/replication). The module is moderate coherence with several weak members. The combination of chromatin remodeling (SMARCA5, EZH2, HDAC2, MBD2), RNA processing (RALY, PRPF40A, SF3B2), nuclear transport (KPNB1), and proteasome (PSMC1, PSMD1) suggests a broad nuclear/chromatin regulatory program. EZH2 and HPRT1 enrichment in prolif_DC supports a proliferation-linked chromatin remodeling context. This is best described as chromatin remodeling in proliferating/activated DCs.
Genes
Most correlated modules
- Inflammatory Stress Response · correlation 0.88
- Cytoskeletal Motor Activity · correlation 0.81
- Cytokine Receptor Signaling · correlation 0.80
- Proteasome & Glycolysis · correlation 0.80
- Mitotic Spindle · correlation 0.79
- Actin Cytoskeleton Remodeling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.