Actin Cytoskeleton Remodeling
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are ACTG1, ACTB (actin isoforms), PFN1 (profilin, actin polymerization), MYL6 (myosin light chain), ACTR3, ARPC2, ARPC4, ARPC5 (Arp2/3 complex subunits driving branched actin nucleation), and TMSB10 (thymosin beta-10, actin sequestering). These genes collectively define a strong actin cytoskeleton/cell motility program. GNG5 (G-protein gamma subunit) and SRI (sorcin, calcium-binding) are consistent with signaling upstream of cytoskeletal remodeling. PSMA2 and PSME1 (proteasome) are peripheral members shared with neighbor M16. The mDC enrichment (2.1x) and strong inflammation correlation suggest this reflects migratory/motile mDC activation. The Arp2/3 complex genes are canonical drivers of lamellipodia and DC migration.
Genes
Most correlated modules
- Inflammatory Stress Response · correlation 0.87
- Mitotic Spindle · correlation 0.84
- Proteasome & Glycolysis · correlation 0.83
- Chromatin Remodeling · correlation 0.77
- Cytoskeletal Motor Activity · correlation 0.76
- Cytokine Receptor Signaling · correlation 0.76
- ER Proteostasis Stress · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.