Cytoskeletal Motor Activity
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The module shows moderate coherence with prolif_DC enrichment (4.5x). ACSL4 (long-chain acyl-CoA synthetase 4, arachidonic acid metabolism/ferroptosis), HSD17B4 (peroxisomal beta-oxidation), and SH3GLB1 (endophilin B1, mitophagy/autophagy) suggest lipid metabolic activity. KIF5B (kinesin-1 heavy chain) and DYNC1I2 (dynein intermediate chain) are microtubule motor proteins involved in organelle transport. ACTN4 (alpha-actinin-4) and CCM2 are cytoskeletal regulators. RAB11B links to recycling endosomes. The combination of motor proteins, cytoskeletal elements, and lipid metabolism in proliferating DCs may reflect the cytoskeletal reorganization and lipid remodeling required during DC division and differentiation. The module is moderately coherent and somewhat mixed, but cytoskeletal/motor activity is the dominant theme.
Genes
Most correlated modules
- Proliferating DC Mixed · correlation 0.85
- Cytokine Receptor Signaling · correlation 0.84
- Chromatin Remodeling · correlation 0.81
- Actin Cytoskeleton Remodeling · correlation 0.76
- Inflammatory Stress Response · correlation 0.74
- ER Proteostasis Stress · correlation 0.74
- Myeloid Stress Response · correlation 0.73
- Mitotic Spindle · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.