Inflammatory Stress Response
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
CSRP1 (cysteine-rich LIM-domain protein, actin cytoskeleton organization) is the top hub and is upregulated in inflammatory contexts. The module shows significant positive delta_inflammation (0.442, sig.) and delta_inflammation_CD (0.583, sig.), the strongest inflammation signal in this batch. ANXA4 (annexin A4, membrane/calcium signaling), SUMO3 (SUMOylation, stress response), MAD2L2 (DNA damage/Rev7), SELENOW (antioxidant selenoprotein), and SDHA (metabolic enzyme) are supporting members. CAMTA1 and THRAP3 are transcriptional regulators. The module is moderate coherence with uniform expression. The inflammation association and CSRP1 hub most strongly support an inflammatory cytoskeletal/stress response program.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.89
- Chromatin Remodeling · correlation 0.88
- Actin Cytoskeleton Remodeling · correlation 0.87
- Proteasome & Glycolysis · correlation 0.80
- Cytokine Receptor Signaling · correlation 0.80
- Cytoskeletal Motor Activity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.