Myeloid Stress Response
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes: CSTB (cystatin B, cysteine protease inhibitor), FTH1 (ferritin heavy chain, iron storage/oxidative stress), ANXA2 (annexin A2, membrane/cytoskeletal), S100A10 and S100A11 (S100 calcium-binding proteins, damage-associated), VIM (vimentin, cytoskeletal), LGALS1 and LGALS9 (galectins, immunomodulatory lectins), ATP6V0E1 (vacuolar ATPase subunit, lysosomal acidification), BRI3 (brain protein I3, anti-apoptotic), CAST (calpastatin, calpain inhibitor), TAGLN2 (transgelin-2, actin-binding). This combination of S100 proteins, galectins, ferritin, vimentin, and protease inhibitors is characteristic of a stress/damage-associated or myeloid activation state. The high mean expression (1.452) and 70% pct positive indicate a broadly expressed housekeeping-like program. S100A10/A11, ANXA2, and VIM together suggest a cytoskeletal/membrane stress response. FTH1 and CSTB point to oxidative and lysosomal stress. The module has moderate coherence with many weak-membership peripheral genes. This resembles a general myeloid stress/activation signature with cytoskeletal and iron-handling components.
Genes
Most correlated modules
- ER Proteostasis Stress · correlation 0.81
- Proliferating DC Mixed · correlation 0.79
- Cytoskeletal Motor Activity · correlation 0.73
- Endosomal Trafficking · correlation 0.72
- Cytokine Receptor Signaling · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.