Endosomal Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes RAB5A, ARF4, ARF6, DENND1B, EHD4, STX12, RHOG, RALB encode core endosomal trafficking machinery: RAB5A marks early endosomes, DENND1B is a RAB35 GEF regulating endocytic recycling, EHD4 controls early-to-recycling endosome transition, STX12 is an endosomal SNARE, ARF4/ARF6 regulate vesicle budding and recycling. The cDC1 enrichment (4.2x overall, up to 3.6x for CD226, 2.8x for EHD4) is consistent with cDC1's specialized endosomal routing for cross-presentation. ERP44 (ER oxidoreductase) and SSR3 link to ER-endosome communication. Neighbor M113 provides the ER chaperone context, and together these modules reflect the ER-to-endosome trafficking axis critical for DC antigen processing.
Genes
Most correlated modules
- Proliferating DC Mixed · correlation 0.83
- ER Protein Folding · correlation 0.83
- Unfolded Protein Response · correlation 0.74
- ER Translocon Processing · correlation 0.74
- Myeloid Stress Response · correlation 0.72
- Cytoskeletal Motor Activity · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.