ER Proteostasis Stress
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
The module has moderate coherence and several weak-membership genes. Hub genes: PPA1 (inorganic pyrophosphatase, metabolic housekeeping), GLIPR2 (Golgi-associated, autophagy/lipid), SEC61B (ER translocon), PSME2 (proteasome activator PA28β, antigen processing), MVP (major vault protein, stress/drug resistance), ALDH2 (mitochondrial aldehyde dehydrogenase), SQOR (sulfide:quinone oxidoreductase, mitochondrial), RAC1 (Rho GTPase, cytoskeletal/signaling), LACTB (mitochondrial serine β-lactamase), FBXO6 (glycoprotein ubiquitin ligase, ER-associated degradation). The combination of ER translocon (SEC61B), proteasome activator (PSME2), FBXO6 (ERAD), and GLIPR2 suggests ER/proteasomal protein quality control. ALDH2, SQOR, LACTB point to mitochondrial metabolic activity. The significant inflammation association and mDC enrichment suggest this is an activation-linked metabolic/proteostasis program. Given the moderate coherence and mixed membership, this likely combines ER stress/proteostasis with mitochondrial metabolism. The dominant signal is ER-associated protein processing.
Genes
Most correlated modules
- IFN-gamma Response · correlation 0.87
- Tolerogenic mDC Activation · correlation 0.83
- Myeloid Stress Response · correlation 0.81
- Proliferating DC Mixed · correlation 0.79
- Cytoskeletal Motor Activity · correlation 0.74
- Actin Cytoskeleton Remodeling · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.