Proliferating DC Mixed
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence and a heterogeneous gene list. The dominant enrichment in prolif_DC (22.7x) and mDC (8.7x) is striking. Hub genes include TMEM50A (transmembrane protein), MYDGF (myeloid-derived growth factor, cytoprotective), CUL1 (cullin-1, SCF ubiquitin ligase), ATP6V0B (vacuolar ATPase subunit, lysosomal acidification), TWF2 (twinfilin-2, actin dynamics), TOP1 (topoisomerase I, DNA replication), SNX6 (sorting nexin, endosomal trafficking), CD47 ('don't eat me' signal), UQCRC2 (mitochondrial complex III), MAP2K2 (MEK2, MAPK signaling), CHMP5 (ESCRT-III, multivesicular body), BAZ1A (chromatin remodeling). The weak coherence and diverse functions suggest this is a mixed module combining proliferation-associated housekeeping (TOP1, CUL1, BAZ1A) with vesicular/endosomal trafficking (SNX6, CHMP5, ATP6V0B) in proliferating DCs. The prolif_DC enrichment is the dominant signal. Given the weak coherence and mixed membership, the best unifying label is proliferating DC housekeeping, but the endosomal trafficking component is notable.
Genes
Most correlated modules
- Cytoskeletal Motor Activity · correlation 0.85
- ER Protein Folding · correlation 0.84
- Endosomal Trafficking · correlation 0.83
- ER Proteostasis Stress · correlation 0.79
- Myeloid Stress Response · correlation 0.79
- Type I Interferon · correlation 0.77
- Cytokine Receptor Signaling · correlation 0.75
- IFN-gamma Response · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.