Mitochondrial Stress Assembly
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The module has moderate coherence and lower expression/detection, suggesting a mixed or less tightly regulated program. HIGD2A and OXA1L are mitochondrial inner membrane assembly factors for Complex IV. NDUFA10 is a Complex I accessory subunit. HMOX2 (heme oxygenase 2) is a mitochondria-associated stress enzyme. These link to neighbor M150's OxPhos theme. CSK (C-terminal Src kinase) phosphorylates and inactivates Src family kinases, a key immune regulatory node. HIKESHI transports HSP70 to the nucleus under heat stress. HPF1 is a PARP1 cofactor in DNA damage response. SENP6 is a SUMO-specific protease involved in genome stability. DICER1 processes miRNAs. CNBP is a zinc-finger transcriptional regulator. METTL9 is a histidine methyltransferase. The module appears to combine mitochondrial assembly/stress with broader cellular stress and regulatory programs. The dominant interpretable theme is mitochondrial stress response and assembly, with regulatory co-travelers, consistent with moderate coherence.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.90
- Ribosome Biogenesis · correlation 0.90
- Proteostasis & Chaperones · correlation 0.88
- ER Protein Biogenesis · correlation 0.88
- Oxidative Stress Response · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.