Ribosome Biogenesis
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes include MRTO4 (ribosome maturation factor), GNL2 (GTPase required for 60S ribosome biogenesis), UTP6 (U3 snoRNP/rRNA processing), PIH1D1 (R2TP complex, snoRNP/ribosome assembly), and MRPL19 (mitochondrial ribosomal protein). These define a ribosome biogenesis program. Additional genes NAXE (metabolic repair), BABAM1 (DNA damage), CLPP (mitochondrial protease), NDUFA8 (Complex I), and ACLY (acetyl-CoA metabolism) reflect the mixed housekeeping nature of this moderate-coherence module. Mild prolif_DC enrichment of DPM2, CLPP, and PIH1D1 is consistent with elevated ribosome biogenesis in proliferating cells. Neighbor context: M124 has proliferating DC markers; M107/M139 are housekeeping — this module fits as a ribosome biogenesis/housekeeping program.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.94
- Vesicular Housekeeping · correlation 0.94
- MYC-driven Proliferation · correlation 0.93
- ER Protein Biogenesis · correlation 0.93
- Mitochondrial DNA Repair · correlation 0.93
- Metabolic Housekeeping · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.91
- Mitochondrial OxPhos · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.