ER Protein Biogenesis
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRPF4 and PRPF38A (pre-mRNA splicing factors), MTREX (RNA exosome targeting complex), DHX9 (RNA helicase), alongside ER-resident genes DDOST (oligosaccharyltransferase), TMED9 (ER cargo receptor), SSR2 (signal sequence receptor), LRPAP1 (ER chaperone), and PDIA4 (ER oxidoreductase). The module combines RNA processing and ER protein biogenesis machinery. Moderate coherence and uniform expression across subsets with mild prolif_DC enrichment suggest a housekeeping program supporting protein synthesis and RNA metabolism. Neighbor context: co-expressed with M20 (RNA processing/proliferation) and M63 (vesicular trafficking), consistent with a coordinated biosynthetic program in proliferating DCs.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.93
- Vesicular Housekeeping · correlation 0.89
- Telomere Maintenance · correlation 0.88
- Mitochondrial Stress Assembly · correlation 0.88
- Endosomal Vesicle Trafficking · correlation 0.87
- Lysosomal Vesicular Trafficking · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.