Oxidative Stress Response
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The module has moderate coherence and a mixed gene composition. CAT (catalase) and PRDX5 (peroxiredoxin 5) are canonical ROS-detoxifying enzymes. NDUFS8 is a Complex I subunit involved in electron transport and ROS generation. ERCC1 is a nucleotide excision repair endonuclease activated by oxidative DNA damage. BAX is a pro-apoptotic BCL2 family member induced by oxidative stress. GLRX3 (in M85 neighbor) and PRDX5 both handle redox balance. PAK1 is activated downstream of oxidative stress and Rac1. GRN (progranulin) has roles in lysosomal stress and inflammation. RAB7A links to endolysosomal trafficking under stress. Some prolif_DC enrichment (NDUFS8, TPRKB, TKT) suggests metabolic upregulation in cycling cells. The dominant theme is oxidative stress response and redox homeostasis, with secondary metabolic/repair components reflecting moderate coherence.
Genes
Most correlated modules
- Mitochondrial DNA Repair · correlation 0.92
- Endosomal Retromer Trafficking · correlation 0.91
- Actin Polymerization · correlation 0.90
- Ribosome Biogenesis · correlation 0.88
- G1/S Cell Cycle · correlation 0.88
- Mitochondrial Stress Assembly · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.