RNA Splicing Processing
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are PTBP1 (polypyrimidine tract-binding protein, splicing regulator), U2SURP (U2 snRNP-associated), SYNCRIP (hnRNP-Q, RNA binding), PRPF31 (pre-mRNA processing factor 31, spliceosome), and IK (splicing factor). These are canonical RNA splicing and processing factors. Additional genes include EIF2S1 (translation initiation), NOL7 (nucleolar), RECQL (DNA helicase), NUDT21 (RNA 3' processing), and TFAM/ISCA2 (mitochondrial, enriched in prolif_DC). The module is enriched in mDC (5x) and shows moderate coherence. The overall signature points to a general RNA processing/splicing housekeeping program active in mDCs. The mild enrichment in prolif_DC for some genes (ISCA2, TFAM, NUDT21) is consistent with elevated RNA metabolism in cycling cells. Neighbor context: this module neighbors M126 and M42, both of which also contain hnRNP/splicing genes, supporting a shared RNA metabolism neighborhood. The mDC enrichment and splicing-centric hub genes distinguish this as an mDC-associated RNA splicing program rather than a pure housekeeping module.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.94
- Ribosome Biogenesis · correlation 0.94
- Mitochondrial Metabolism UCP2 · correlation 0.93
- Proteostasis & Chaperones · correlation 0.92
- Metabolic Housekeeping · correlation 0.91
- Mitochondrial DNA Repair · correlation 0.91
- Mitochondrial Stress Assembly · correlation 0.90
- Mitochondrial Biogenesis · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.