Proteostasis & Chaperones
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and moderate mean expression (~35% detection) with uniform expression across subsets. Hub genes include PFDN6 (prefoldin subunit 6 — chaperone for actin/tubulin folding), CCT4 (chaperonin containing TCP1 subunit 4 — TRiC/CCT complex), HSPA4 (HSP70 family chaperone), PSMB7 (proteasome beta subunit), MRPS36/MRPS10 (mitochondrial ribosomal proteins), PDCD6 (apoptosis-linked gene 2 / ALG-2, calcium-binding), RNF7 (RING finger E3 ubiquitin ligase), CYCS (cytochrome c — mitochondrial apoptosis), PDHA1 (pyruvate dehydrogenase alpha — TCA cycle entry), and FRG1 (actin bundling). The dominant theme is protein folding/chaperone activity (PFDN6, CCT4, HSPA4) combined with proteasome (PSMB7) and ubiquitin (RNF7) — a proteostasis program. CYCS and PDHA1 add mitochondrial metabolic context. The module is significantly upregulated in CD inflammation. Neighbor context: M72 contains CCT7/CCT8 (also TRiC subunits), and M112 contains PSMD3 (proteasome), confirming a neighborhood of proteostasis and metabolic programs. The chaperone/TRiC signature is the most specific element here.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.92
- RNA Splicing Processing · correlation 0.91
- Mitochondrial Metabolism UCP2 · correlation 0.90
- Mitochondrial Biogenesis · correlation 0.90
- Oxidative Phosphorylation · correlation 0.89
- Mitochondrial Ribosome Biogenesis · correlation 0.88
- Mitochondrial Stress Assembly · correlation 0.88
- Actin Polymerization · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.