Alternative Splicing
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include RSRP1, N4BP2L2, PNISR, PRPF38B, SRRM2, CLK1, SCAF11 — all splicing-related factors (SRRM2 is a splicing co-activator, PRPF38B is a pre-mRNA processing factor, CLK1 is a kinase that phosphorylates SR proteins, PNISR and SCAF11 are splicing regulators, RSRP1 is an SR-related protein). INTS6 is part of the Integrator complex involved in RNA Pol II regulation. AKNA is a transcription factor. MYO9B is a myosin involved in cytoskeletal dynamics. The module is strongly enriched in cDC2 (15.2x), suggesting a cDC2-specific splicing/RNA processing program. CLK1 as a hub kinase for SR protein phosphorylation, combined with multiple SR-domain proteins, points to regulated alternative splicing as the core program.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.87
- Chromatin Remodeling · correlation 0.85
- Transcriptional Homeostasis · correlation 0.84
- mRNA Splicing · correlation 0.82
- Immediate Early Response · correlation 0.79
- Endosomal DC Trafficking · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.