Mitochondrial OxPhos
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes include multiple NADH dehydrogenase subunits (NDUFB7, NDUFA2, NDUFS5, NDUFB10), ubiquinol-cytochrome c reductase subunits (UQCR10, UQCRQ), COX8A (cytochrome c oxidase), ATP5PD (ATP synthase), MDH2 (TCA cycle), and TIMM13 (mitochondrial import). These are canonical oxidative phosphorylation and mitochondrial respiratory chain components. Additional genes like C1QBP (mitochondrial ribosome/OxPhos regulator), AURKAIP1 (mitochondrial ribosome), and MRPS15 (mitochondrial ribosomal protein) reinforce mitochondrial identity. LSM7, SNU13, SNRPF are spliceosomal components that may co-vary with metabolic activity. LAMTOR1 links to lysosomal mTOR signaling. The module is enriched in cDC1s and shows strong coherence. This is primarily a mitochondrial OxPhos program.
Genes
Most correlated modules
- Spliceosome RNA Processing · correlation 0.96
- Ribosome Biogenesis · correlation 0.94
- Mitochondrial Biogenesis · correlation 0.92
- Mitochondrial DNA Repair · correlation 0.91
- Mitochondrial OxPhos · correlation 0.91
- Mitochondrial Metabolism UCP2 · correlation 0.90
- Oxidative Phosphorylation · correlation 0.89
- Mitochondrial Ribosome Biogenesis · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.