Mitochondrial Biogenesis
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence, low mean expression (~20% detection), and uniform expression across subsets. Hub genes include CUEDC2 (ubiquitin-related, cell cycle regulation), MRPL9/MRPL40 (mitochondrial ribosomal proteins), MCTS1 (translation re-initiation factor), PPID (peptidyl-prolyl isomerase D / cyclophilin D, mitochondrial), THOC6 (THO complex, mRNA export), MFF (mitochondrial fission factor), BCCIP (BRCA2/CDKN1A interacting), CTNNBL1 (spliceosome), UBE2E3 (ubiquitin conjugating enzyme), DHRS4L2 (short-chain dehydrogenase), VPS25 (ESCRT-II), COA5 (cytochrome c oxidase assembly), ETFA (electron transfer flavoprotein alpha, fatty acid oxidation), and HDAC3 (histone deacetylase). The module blends mitochondrial ribosome/assembly (MRPL9, MRPL40, COA5, PPID), RNA processing (THOC6, CTNNBL1), ubiquitin pathway (CUEDC2, UBE2E3), and mitochondrial dynamics (MFF). The moderate coherence reflects this mixed composition. Neighbor context: sits alongside M72 (OxPhos) and M112 (metabolic housekeeping), consistent with a mitochondrial biogenesis/maintenance theme. The mitochondrial ribosomal and assembly genes are the most coherent sub-program.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.92
- Oxidative Phosphorylation · correlation 0.92
- Metabolic Housekeeping · correlation 0.92
- Endocytic Vesicular Trafficking · correlation 0.92
- Mitochondrial Metabolism UCP2 · correlation 0.91
- Mitochondrial DNA Repair · correlation 0.90
- Mitochondrial Ribosome Biogenesis · correlation 0.90
- Proteostasis & Chaperones · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.