Tolerogenic cDC2 State
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include SYTL1 (synaptotagmin-like protein, vesicle trafficking/secretion), PLAU (urokinase plasminogen activator, tissue remodeling/migration), XBP1 (ER stress/UPR transcription factor, also key for DC differentiation and tolerogenic function), HIP1 (clathrin-mediated endocytosis), PLIN2 (lipid droplet protein), ATP11A (phospholipid flippase), GNG2 (G-protein signaling), HAVCR2 (TIM-3, immune checkpoint/tolerance receptor), HES1 (Notch target, cDC2 identity), FGD4 (Rho-GEF, cytoskeletal), PABPC4 (RNA binding), IFT20 (intraflagellar transport/vesicle trafficking). The combination of XBP1, HAVCR2 (TIM-3), HES1 (Notch/cDC2), and PLIN2 (lipid metabolism) points toward a tolerogenic/regulatory cDC2 state with ER stress and lipid-loading features. PLAU and SYTL1 add secretory/migratory capacity. This is consistent with a tolerogenic or exhausted DC state. The neighbor M148 also shows cDC2 inhibitory receptor enrichment, supporting a tolerogenic cDC2 neighborhood. XBP1 is a known driver of tolerogenic DC function and lipid metabolism in DCs.
Genes
Most correlated modules
- Golgi-Endosomal Trafficking · correlation 0.83
- DC Metabolic Activation · correlation 0.82
- AP-1 cDC2 Activation · correlation 0.81
- DC Proliferation Program · correlation 0.81
- Acute Inflammatory Activation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.