Golgi-Endosomal Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Moderate coherence, mDC-enriched module. STT3B (oligosaccharyltransferase, N-glycosylation in ER), GOLIM4 (Golgi integral membrane protein), VPS26A (retromer subunit, endosomal cargo retrieval), ATP6V0A1 (V-ATPase a1 subunit, endolysosomal acidification), CORO1C (actin regulator involved in vesicle trafficking), and RALBP1 (RAL effector, vesicular transport) collectively define a Golgi/endosomal vesicular trafficking program. NFATC1 may reflect downstream signaling. The mDC enrichment and these trafficking genes suggest active antigen processing-related vesicular transport.
Genes
Most correlated modules
- Cell Cycle Checkpoint · correlation 0.86
- Lysosomal Vesicular Trafficking · correlation 0.86
- Tolerogenic Lipid Metabolism · correlation 0.85
- Glucocorticoid Stress Response · correlation 0.84
- DC Proliferation Program · correlation 0.84
- DC Actin Migration · correlation 0.83
- Tolerogenic cDC2 State · correlation 0.83
- Phagocytic Cytoskeletal · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.