DC Metabolic Activation
Gene co-expression module in Dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include METRNL (meteorin-like, tissue-repair cytokine), CREM (cAMP-responsive transcription factor), PPIF (cyclophilin D, mitochondrial permeability transition pore regulator), EZR (ezrin, cytoskeletal/membrane), PLAUR (uPAR, migration and ECM remodeling), SLC7A5 (LAT1, amino acid transporter), SLC2A3 (GLUT3, glucose transporter), and SKIL (SnoN, TGF-β signaling). LPXN (leupaxin) and LIMS1 are focal adhesion proteins. The combination of nutrient transporters, cytoskeletal/adhesion genes, and PLAUR suggests metabolic activation coupled to migratory capacity in cDC2s. THBD (thrombomodulin) marks a regulatory DC state.
Genes
Most correlated modules
- OLR1+ cDC2 Subset · correlation 0.91
- AP-1 cDC2 Activation · correlation 0.90
- Tolerogenic Lipid Metabolism · correlation 0.89
- Actin Cytoskeletal Remodeling · correlation 0.87
- DC Proliferation Program · correlation 0.85
- MMP9 Effector cDC2 · correlation 0.85
- Tolerogenic DC Signaling · correlation 0.83
- Glucocorticoid Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.