DC Proliferation Program
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Extremely strong prolif_DC enrichment (37.7x) is the dominant signal. FBXW7 (ubiquitin E3 ligase targeting cyclin E and c-Myc, key cell cycle regulator), DUSP6 and DUSP10 (MAPK phosphatases that modulate ERK/p38 post-mitogenic signaling), FNIP1 (FLCN-interacting protein, mTORC1 regulation and cell growth), RRAD (Ras-related GTPase involved in cell cycle), and ANKRD28 (regulatory scaffold) support a proliferation-associated regulatory program. SLC16A3 (lactate/monocarboxylate transporter) and SLC25A44 suggest metabolic adaptation during proliferation. This module captures the regulatory and metabolic program of proliferating DCs.
Genes
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.87
- Glucocorticoid Stress Response · correlation 0.87
- DC Metabolic Activation · correlation 0.85
- OLR1+ cDC2 Subset · correlation 0.85
- Tolerogenic DC Signaling · correlation 0.84
- NRF2 Metabolic Stress · correlation 0.84
- Golgi-Endosomal Trafficking · correlation 0.84
- Tolerogenic cDC2 State · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.