AP-1 cDC2 Activation
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include FOSL2, CEBPB, CEBPD (AP-1/C/EBP transcription factors), SNAI1, ZNF331, GZF1, TIPARP, and RGS2 — forming a coherent AP-1/C/EBP immediate-early transcriptional activation program. AREG (amphiregulin) and GABARAPL1 (autophagy) are consistent with an activated cDC2 state. Strong cDC2 enrichment across nearly all genes. TIPARP links to AhR signaling. This module represents the AP-1-driven transcriptional response in activated cDC2s, consistent with a tolerogenic or tissue-repair activation state given AREG expression.
Genes
Most correlated modules
- p53 Transcriptional Regulation · correlation 0.92
- DC Metabolic Activation · correlation 0.90
- Actin Cytoskeletal Remodeling · correlation 0.89
- Glucocorticoid Stress Response · correlation 0.88
- MMP9 Effector cDC2 · correlation 0.88
- OLR1+ cDC2 Subset · correlation 0.87
- Tolerogenic Lipid Metabolism · correlation 0.87
- Immediate Early Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.