RNA Processing Proliferation
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 39 genes have a known function matching the annotation |
Why this annotation
Hub genes include XPO1 (exportin-1, nuclear export of RNA and proteins), RNPS1 (RNA processing/splicing activator), SRSF10 (serine/arginine-rich splicing factor), SF3A2 (splicing factor 3A subunit), NOP56 (box C/D snoRNP, rRNA processing), MTREX (RNA exosome targeting), and DYRK1A (kinase regulating splicing and cell cycle). MASTL (microtubule-associated serine/threonine kinase-like, mitotic entry kinase) is strongly enriched in prolif_DC (3.7x), and PIK3CD (PI3K-delta) and DNM1L (dynamin-like GTPase, mitochondrial fission) add proliferation/metabolic context. USP22 (deubiquitinase, histone H2B, cell cycle). The module reflects RNA processing and nuclear export machinery upregulated in proliferating DCs, with MASTL as a proliferation anchor. Neighbor context: shares RNA processing theme with M37 and prolif_DC enrichment with M146.
Genes
Most correlated modules
- Genome Maintenance · correlation 0.88
- Phagocytic Cytoskeletal · correlation 0.86
- DC Proliferation Program · correlation 0.85
- Telomere Maintenance · correlation 0.85
- Endosomal Vesicle Trafficking · correlation 0.85
- Endosomal DC Program · correlation 0.85
- ER Membrane Biogenesis · correlation 0.84
- Golgi-Lysosome Trafficking · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.