ER Translocon Processing
Gene co-expression module in Dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
Despite weak coherence and many weak-membership genes, a coherent sub-program is identifiable: SEC11C (signal peptidase complex subunit), DAD1 (oligosaccharyltransferase subunit, N-glycosylation), HM13 (signal peptide peptidase, intramembrane protease), SSR4 (translocon-associated protein delta, TRAP complex), KDELR2 (ER retention/retrieval receptor for KDEL-bearing proteins) — all ER membrane/translocon components involved in co-translational protein import and processing. FLOT1 (flotillin-1, lipid raft scaffold) and CD59 (GPI-anchored complement regulator) add a membrane microdomain component. SRA1 (steroid receptor RNA activator) has weak membership and may be peripheral. In the context of neighboring M113 (ER chaperones) and M103 (UPR), this module represents the ER translocon and signal peptide processing machinery, completing the ER protein biogenesis neighborhood.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.84
- Type I Interferon · correlation 0.82
- Unfolded Protein Response · correlation 0.78
- ER Protein Processing · correlation 0.77
- Endosomal Trafficking · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.