Nucleotide Biosynthesis
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes include IDH2 (TCA cycle, also nucleotide metabolism), PA2G4 (EBP1, ribosome biogenesis/proliferation), AKR7A2 (aldo-keto reductase), SNRPB, SNRPD3 (snRNP/spliceosome), PAICS (de novo purine synthesis), NME1, NME4 (nucleoside diphosphate kinases, nucleotide supply for replication), ALYREF (mRNA export), DCTPP1 (dCTP pyrophosphatase, nucleotide pool maintenance), RNASEH2C (Okazaki fragment processing), DEK (chromatin remodeling in proliferating cells), EIF4EBP1 (translation regulation), BRIX1 (ribosome biogenesis), SRM (spermidine synthase, polyamine synthesis for proliferation), HNRNPD (mRNA stability), PRDX2 (redox). Nearly all genes are enriched 2-4x in prolif_DC. The dominant program is nucleotide biosynthesis and supply for DNA replication, combined with ribosome biogenesis — a classic S-phase/proliferation signature. Neighbor context: M89 has spliceosome/RNA processing enriched in prolif_DC; M23 complements it with nucleotide metabolism and ribosome biogenesis, both supporting active cell division.
Genes
Most correlated modules
- DC Proliferation · correlation 0.97
- Mitotic Proliferation · correlation 0.95
- DNA Replication Chromatin · correlation 0.95
- Spliceosome RNA Processing · correlation 0.94
- Complex I Assembly · correlation 0.90
- S-phase Replication · correlation 0.89
- RNA Splicing Processing · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.