Mitotic Proliferation
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
This module is strongly enriched in prolif_DC (most genes 2.9–4.5x). Hub genes include HNRNPAB (RNA binding, cell cycle), ANAPC15 (APC/C complex, mitotic exit), DNMT1 (DNA methylation maintenance during replication), HAUS1 (augmin complex, spindle assembly), CENPX (centromere protein, kinetochore), PRPS2 (purine synthesis for DNA replication), PMF1 (spindle assembly checkpoint), PSMG1 (proteasome assembly), FUNDC1 (mitophagy), YWHAH (14-3-3 protein, cell cycle checkpoint), NUDT5 (nucleotide metabolism), CMSS1 (cell cycle). The combination of centromere (CENPX), spindle (HAUS1, PMF1), APC/C (ANAPC15), DNA methylation (DNMT1), and purine synthesis (PRPS2) genes is a clear cell cycle/proliferation signature, specifically mitotic. This is a proliferating DC module.
Genes
Most correlated modules
- Nucleotide Biosynthesis · correlation 0.95
- Spliceosome RNA Processing · correlation 0.95
- DC Proliferation · correlation 0.94
- Endocytic Vesicular Trafficking · correlation 0.94
- MYC-driven Proliferation · correlation 0.94
- DNA Replication Chromatin · correlation 0.93
- Mitochondrial OxPhos · correlation 0.91
- Metabolic Housekeeping · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.