LMX1A/VMAT1 EC identity
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 19 genes have a known function matching the annotation |
Why this annotation
This core-coherent module is driven by the EC-specifying transcription factor LMX1A (24x), the vesicular monoamine transporter SLC18A1 (VMAT1), CHGA, and the EC granule genes SYT13 and RAB3C. Together these form the EC transcriptional identity and serotonin vesicle-loading arm, which complements the TPH1/DDC synthesis arm in «Serotonin biosynthesis».
Genes
Most correlated modules
- Serotonin biosynthesis · correlation 0.84
- GULP1/PRDM16 EC genes · correlation 0.84
- Serotonergic EC specification · correlation 0.80
- GREM2/CDH26 EC subset · correlation 0.80
- SV2C/KCNS3 EC program · correlation 0.80
- CALCR/CDHR3 EC program · correlation 0.77
- EC Neuronal Excitability · correlation 0.75
- TRPA1/ADH4 chemosensory EC · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.