EC Neuronal Excitability
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Nearly every gene peaks in EC cells (GRIA4 3.1x, MYO5A 2.9x, UBE2E2 3.2x), with secondary D-cell signal. The module is a neuron-like excitability toolkit: the AMPA receptor GRIA4, the GIRK channel KCNJ6 with its regulator GNB5, the Kv subunit KCNG3, the Nav modulator FGF14, the granule motor MYO5A and the neuronal splicing factor NOVA1. Its tight correlation with Serotonergic EC specification supports an EC origin over contamination.
Genes
Most correlated modules
- LMX1A/VMAT1 EC identity · correlation 0.75
- CASR/GIRK membrane sensing · correlation 0.71
- SCN3A/HCN1 EC excitability · correlation 0.65
- CES1/TRPC7 EC subset · correlation 0.59
- RASGRP1/MME K-cell signaling · correlation 0.52
- Serotonergic EC specification · correlation 0.49
- TRPA1/ADH4 chemosensory EC · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.