Peptidergic Secretory Granule
Gene co-expression module in Enteroendocrine cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
The hub genes are dense-core granule machinery: the prohormone-convertase chaperones PCSK1N and SCG5, the granin SCG2, and the exocytosis regulators CPLX2 and SCIN. They are enriched across the N/I/K/D/INSL5 peptidergic lineages rather than in a single subset, marking a shared peptidergic secretory program distinct from enterochromaffin cells. Peripheral cytoskeletal and enterocyte-typical genes make the call less definitive.
Genes
Most correlated modules
- Neurotensin N-cell Program · correlation 0.63
- NPW terminal maturation · correlation 0.61
- Small-intestinal Nutrient Sensing · correlation 0.59
- Secretin/epithelial co-program · correlation 0.59
- INSL5/N-cell epithelial state · correlation 0.58
- Peptidergic branch genes · correlation 0.58
- CASR/GIRK membrane sensing · correlation 0.56
- CLU/PDZK1 I-cell program · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.