Basal Housekeeping
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 7 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence overall with all hub genes showing weak membership. The top genes include NSL1 (kinetochore/chromosome segregation), DUT (dUTPase, DNA replication/repair), POLR2C (RNA polymerase II subunit), LSM10 (snRNA processing), SDHAF2 (succinate dehydrogenase assembly), and PSENEN (presenilin enhancer/gamma-secretase). These genes span multiple housekeeping functions — DNA metabolism, RNA processing, mitochondrial complex II assembly — without a coherent single program. The ILC1 enrichment (~2x) is modest and likely reflects a slightly more active baseline state in ILC1s. The module appears to be a loosely co-regulated housekeeping/basal metabolism module rather than a specific biological program. Given the mix of DNA replication (DUT), RNA pol (POLR2C), snRNA processing (LSM10), and mitochondrial assembly (SDHAF2), the best label is a general housekeeping/basal transcription module. The neighbor context (M100, M39) also shows weak, mixed modules, consistent with a neighborhood of low-coherence housekeeping programs.
Genes
DUT, LSM10, NSL1, POLR2C, PSENEN, SDHAF2, SMIM19
Most correlated modules
- RNA Processing Mixed · correlation 0.91
- ILC1 Actin Motility · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.