NSL1 — NSL1 component of MIS12 kinetochore complex
NSL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Basal Housekeeping RNA processing & translation | DUT, LSM10, POLR2C, PSENEN, SDHAF2, SMIM19 | View in SCUBA |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2 +20 more | View in SCUBA |
| Monocytes | DNA Damage Response Stress | AGPAT5, ATM, CALM2, DCAF7, FAM13A, GPR155, MEF2C, NLN +4 more | View in SCUBA |
About the gene
| Synonyms | C1orf48, DC8, DKFZP566O1646, MIS14 |
|---|---|
| Chromosome | 1: 212726153-212791782 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Chromosome partition, Mitosis |
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.