PSENEN — Presenilin enhancer, gamma-secretase subunit
PSENEN belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSENEN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | SR Kinase & RNA RNA processing & translation | ADHFE1, ATF2, BCAP31, C4orf3, CCPG1, CHKB, CLK2, EFR3A +17 more | |
| Innate lymphoid cells | Basal Housekeeping RNA processing & translation | DUT, LSM10, NSL1, POLR2C, SDHAF2, SMIM19 | View in SCUBA |
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 more | View in SCUBA |
About the gene
| Synonyms | PEN2 |
|---|---|
| Chromosome | 19: 35745600-35747519 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
| Biological process | Notch signaling pathway |
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.