RNA Processing Mixed
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Weak coherence module with low mean expression and detection rate, no dominant subset. Hub genes include translation initiation (DENR, EIF4H), RNA processing (PHAX, RBM42, FYTTD1, TIAL1, IMP3), ubiquitin/proteasome (RBCK1, PSMF1), and lysosomal (FUCA1, B3GAT3) components. The most coherent sub-theme is RNA processing and translation, though the module is mixed. KLRC1 (NKG2A) is a peripheral ILC1/NK marker. The weak coherence and low expression suggest a loosely co-regulated housekeeping/RNA metabolism program in ILC1 cells rather than a tight biological program.
Genes
AUP1, B3GAT3, CFDP1, CMTM3, DENR, EIF4H, FBXW5, FUCA1, FYTTD1, IMP3, KLRC1, MITD1, MTCH1, PHAX, PLEKHJ1, PSMF1, RBCK1, RBM42, SEPHS2, SNX14, TIAL1, UBE2G1
Most correlated modules
- ILC1 Actin Motility · correlation 0.92
- Basal Housekeeping · correlation 0.91
- Ubiquitin Stress Response · correlation 0.91
- JAK-STAT Cytokine Signaling · correlation 0.89
- ILC1 Lymphocyte Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.