Centrosome Biogenesis
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include TTF2 (transcription termination factor/DNA helicase), POLQ (DNA polymerase theta, alt-NHEJ/replication stress repair), CENPJ (centrosome/centriole biogenesis), CEP152 (centriole duplication, PLK4 scaffold), MIS18BP1 (CENP-A loading at centromeres), HP1BP3 (heterochromatin/chromatin organization), NSD2 (histone H3K36 methyltransferase, DNA repair and replication), CCDC18 (centrosome/cilia). The module centers on centrosome biogenesis and chromatin/epigenetic regulation during cell cycle. CENPJ, CEP152, and MIS18BP1 are centrosome/kinetochore factors; NSD2 and HP1BP3 link to chromatin compaction; POLQ and TTF2 link to DNA transactions. This is a centrosome biogenesis and chromatin organization module active in cycling progenitors. Neighbor context: adjacent to M81 (kinetochore/S-phase) and M28 (G2/M), consistent with a cell cycle chromatin/centrosome program.
Genes
Most correlated modules
- Replication Stress Response · correlation 0.89
- Mitotic Spindle · correlation 0.82
- DNA Replication/Repair · correlation 0.81
- Mitotic Spindle · correlation 0.80
- G2/M Mitosis · correlation 0.75
- DNA Repair S-phase · correlation 0.74
- G2/M Kinase · correlation 0.64
- Replication Initiation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.