Mitotic Spindle
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical mitotic spindle assembly and chromosome segregation factors: NCAPG (condensin), KIF11 (Eg5 kinesin, bipolar spindle), KIFC1 (minus-end kinesin), HJURP (CENP-A chaperone), BUB1B (spindle assembly checkpoint), KIF15 (spindle kinesin), NDC80 (kinetochore-microtubule attachment), ANLN (anillin, cytokinesis), AURKB (Aurora B kinase, chromosome alignment), NUSAP1 (spindle-associated), KIF2C (MCAK, microtubule depolymerization). This is a tight mitotic spindle/chromosome segregation module. All genes are core members with uniform expression, consistent with a proliferating progenitor subpopulation. Neighbor context: flanked by M82 (S-phase/DNA repair) and M81 (kinetochore/S-phase), confirming a cell cycle cluster.
Genes
Most correlated modules
- G2/M Mitosis · correlation 0.97
- Mitotic Spindle · correlation 0.94
- G2/M Kinase · correlation 0.90
- S/G2 Transition · correlation 0.87
- DNA Replication/Repair · correlation 0.83
- Centrosome Biogenesis · correlation 0.82
- Nuclear Architecture · correlation 0.81
- Replication Stress Response · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.