Epithelial Cell Adhesion
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes DSG2 (desmoglein-2, desmosomal cadherin) and CDH1 (E-cadherin, adherens junction) are the two canonical epithelial cell-cell adhesion molecules. MAL2 mediates transcytosis in polarized epithelial cells. CANX (calnexin) supports glycoprotein folding of junction proteins. TSPAN3 and RAB10 participate in vesicular trafficking supporting junction maintenance. PRKAR2A (PKA regulatory subunit) modulates junction signaling. TM9SF2/3 are lysosomal proteins. GNB1 is a G-protein subunit. The module is anchored by a strong epithelial adhesion junction signature. Neighbor modules M52 and M61 involve glycoprotein processing, consistent with biosynthesis and trafficking of junction proteins.
Genes
Most correlated modules
- ER Protein Translocation · correlation 0.94
- Protein Glycosylation · correlation 0.92
- Mitochondrial Cristae Organization · correlation 0.91
- Mitochondrial Fatty Acid Oxidation · correlation 0.90
- Golgi Secretory Processing · correlation 0.89
- ER Targeting & Trafficking · correlation 0.88
- ER Membrane Organization · correlation 0.88
- Housekeeping Transcription · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.