Mitochondrial Cristae Organization
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub gene PKP2 (plakophilin-2) is a desmosomal armadillo protein critical for epithelial junction integrity. TMOD3 (tropomodulin-3) caps actin filament pointed ends, linking to cytoskeletal organization. IMMT (mitofilin/IMMT) organizes mitochondrial inner membrane cristae. IARS2 is a mitochondrial isoleucyl-tRNA synthetase. CS (citrate synthase) is the entry enzyme of the TCA cycle. RBM47 is an RNA-binding protein. CDS1 synthesizes CDP-diacylglycerol for phospholipid biosynthesis including cardiolipin (mitochondrial). CD164 is a sialomucin. The module bridges desmosomal/cytoskeletal (PKP2, TMOD3) and mitochondrial organization (IMMT, IARS2, CS, CDS1) programs. Given neighbor M48 is a strong mitochondrial module, and the mitochondrial genes here include cristae organization (IMMT) and TCA (CS), this module likely represents mitochondrial structural organization co-regulated with epithelial junction maintenance in colonocytes.
Genes
Most correlated modules
- Epithelial Cell Adhesion · correlation 0.91
- ER Protein Translocation · correlation 0.88
- Mitochondrial Fatty Acid Oxidation · correlation 0.88
- Protein Glycosylation · correlation 0.85
- Golgi Secretory Processing · correlation 0.85
- Cytoskeletal Junction · correlation 0.82
- DNA Damage Repair · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.