Golgi Secretory Processing
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include CTSS (lysosomal cysteine protease), GOLM1 (Golgi membrane protein involved in secretory pathway), PRSS3 (serine protease/trypsinogen), PPIC (peptidyl-prolyl isomerase/cyclophilin C supporting protein folding), and ATP8B1 (phospholipid flippase critical for bile acid transport and membrane integrity). AKR1C3 participates in steroid/prostaglandin metabolism. PYCARD (ASC inflammasome adaptor) is a peripheral member. The dominant theme is Golgi/lysosomal proteolytic processing and secretory pathway function. Neighbor context with M52 (glycosylation/vesicular trafficking) supports a secretory processing program.
Genes
Most correlated modules
- Epithelial Cell Adhesion · correlation 0.89
- Mature Colonocyte · correlation 0.88
- S100 Cytoskeletal Stress · correlation 0.87
- Mitochondrial Sulfur Detox · correlation 0.86
- ER Protein Translocation · correlation 0.85
- Mitochondrial Fatty Acid Oxidation · correlation 0.85
- Mitochondrial Cristae Organization · correlation 0.85
- Epithelial Stress Repair · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.