S/G2 Transition
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
CKS1B (CDK regulatory subunit, S/G2/M), CENPW (kinetochore, mitosis), DTYMK (thymidylate kinase, dNTP synthesis for S-phase), MAD2L1 (spindle assembly checkpoint), PBK (mitotic kinase), CENPN (kinetochore), POC1A (centriole assembly), BUB3 (spindle checkpoint), SKA2 (kinetochore-microtubule attachment), SAP30 (Sin3 complex, cell cycle transcription). This module spans S-phase dNTP synthesis, kinetochore assembly, and spindle checkpoint — a mixed S/G2/M transition module. Negative delta_inflammation_CD and positive delta_treatment_CD suggest modulation by CD disease activity. Neighbor context: sits between S-phase modules (M38, M76) and mitotic modules (M56, M34), consistent with a G1/S-to-mitosis transition program.
Genes
Most correlated modules
- Nuclear Architecture · correlation 0.94
- G2/M Mitosis · correlation 0.92
- Mitotic Spindle · correlation 0.87
- G2/M Kinase · correlation 0.86
- S-phase Progression · correlation 0.81
- DNA Replication/Repair · correlation 0.79
- Mitotic Spindle · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.