G2/M Kinase
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are all G2/M kinases and regulators: NEK2 (centrosome separation), PLK1 (master mitotic kinase), CCNB1 (cyclin B1, G2/M), DLGAP5 (spindle assembly), DEPDC1 (G2/M transcription factor), HMMR (spindle assembly), BUB1 (spindle assembly checkpoint), KNSTRN (kinetochore), CENPA (centromere), CDC20 (APC/C activator), CKAP2 (spindle), AURKA (Aurora A kinase). This is a tight G2/M kinase and mitotic entry module. All genes are core members. Decreased in remission (negative delta_remission_UC), consistent with reduced proliferation in remission. Neighbor context: closely related to M56 (mitotic spindle execution) but focused on G2/M kinase signaling and mitotic entry.
Genes
Most correlated modules
- G2/M Mitosis · correlation 0.96
- Mitotic Spindle · correlation 0.92
- Mitotic Spindle · correlation 0.90
- S/G2 Transition · correlation 0.86
- Nuclear Architecture · correlation 0.78
- Centrosome Biogenesis · correlation 0.64
- DNA Replication/Repair · correlation 0.59
- Replication Stress Response · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.