G2/M Mitosis
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 14 genes have a known function matching the annotation |
Why this annotation
All genes are canonical G2/M regulators: TPX2 (spindle assembly factor, Aurora A activator), RACGAP1 (centralspindlin, cytokinesis), CDCA3 (Tome-1, CDK1 activator), KIF23 (MKLP1, central spindle/cytokinesis), CDK1 (master mitotic kinase), TOP2A (topoisomerase II, chromosome decatenation), KIF20B (cytokinesis kinesin), CDCA8 (borealin/Survivin complex), CCNA2 (cyclin A2, G2/M), UBE2C (APC/C ubiquitin conjugating enzyme, mitotic exit), TTK (Mps1, spindle checkpoint), CDCA2 (Repo-Man, chromosome decondensation), HMGB2 (chromatin), PARPBP (PARP binding). This is a tightly coherent G2/M mitosis module. Neighbor context: flanked by M81 (S-phase) and M77 (DNA repair/replication stress), consistent with a late cell cycle position.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.97
- G2/M Kinase · correlation 0.96
- Mitotic Spindle · correlation 0.94
- S/G2 Transition · correlation 0.92
- Nuclear Architecture · correlation 0.85
- DNA Replication/Repair · correlation 0.77
- Centrosome Biogenesis · correlation 0.75
- S-phase Progression · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.