Mitotic Spindle
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical mitotic markers: ASPM (spindle pole), CENPE (kinetochore motor), GTSE1 (microtubule stabilization in mitosis), KNL1 (kinetochore scaffold), CENPF (kinetochore), GPSM2 (spindle orientation), SGO2 (centromeric cohesion), MKI67 (mitosis marker), TROAP (spindle assembly), TACC3 (centrosome/spindle), KIF14 (cytokinesis kinesin), CIT (citron kinase, cytokinesis), PRR11 (G2/M). This is a tight late G2/M mitotic spindle and cytokinesis module. Increased in UC inflammation, decreased in remission — consistent with elevated proliferation during active disease. Neighbor context: complements M34 (G2/M kinases) and M63 (spindle assembly checkpoint) as distinct mitotic sub-programs.
Genes
Most correlated modules
- G2/M Mitosis · correlation 0.94
- Mitotic Spindle · correlation 0.94
- G2/M Kinase · correlation 0.92
- Centrosome Biogenesis · correlation 0.80
- S/G2 Transition · correlation 0.77
- Nuclear Architecture · correlation 0.76
- Replication Stress Response · correlation 0.69
- DNA Replication/Repair · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.