Nuclear Architecture
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 16 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include LMNB1 and LMNB2 (nuclear lamins B1/B2, nuclear envelope structure), TMPO (thymopoietin/LAP2, nuclear envelope/chromatin tethering), SMC2 and SMC4 (condensin complex subunits, chromosome compaction), RAD21 (cohesin, sister chromatid cohesion), HMGB1, HMGB2, HMGB3 (high mobility group chromatin proteins), HMGN2 (nucleosome binding), MIS18A (centromere maintenance), LBR (lamin B receptor, nuclear envelope-chromatin), VRK1 (nuclear kinase, histone H3 phosphorylation, cell cycle entry), NUCKS1 (chromatin remodeling, DNA repair), ANP32B and ANP32E (chromatin/histone chaperones), NDC1 (nuclear pore). This module captures nuclear envelope organization, chromatin compaction, and cohesin/condensin activity — the nuclear architecture program of cycling cells preparing for or exiting mitosis. Higher mean expression (0.535) and pct positive (41.7%) than other modules in this batch suggests broader expression across progenitors, consistent with a general nuclear organization program in proliferating cells. Neighbor context: sits within the cell cycle cluster; the nuclear lamins and condensins link to chromosome compaction in M/G1.
Genes
Most correlated modules
- S/G2 Transition · correlation 0.94
- Chromatin RNA Processing · correlation 0.88
- G2/M Mitosis · correlation 0.85
- Mitotic Spindle · correlation 0.81
- S-phase Progression · correlation 0.80
- Nuclear Housekeeping · correlation 0.79
- G2/M Kinase · correlation 0.78
- DNA Replication/Repair · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.