Co-translational Chaperoning
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
NACA (nascent polypeptide-associated complex alpha) and BTF3 (beta subunit of NAC) form the nascent polypeptide-associated complex (NAC), which associates with ribosomes and emerging polypeptides to prevent misfolding and mistargeting. PFDN5 is a prefoldin subunit (chaperone for nascent proteins). TPT1 (TCTP) regulates translation and protein synthesis. TOMM7 is part of the TOM mitochondrial import complex. ATP5MC2 is an ATP synthase subunit (linking to OxPhos neighbors). FTH1/FTL encode ferritin heavy and light chains (iron storage, stress response). COMMD6 is involved in copper metabolism and NF-κB regulation. UXT is a prefoldin-like chaperone. The module bridges co-translational protein quality control with mitochondrial function.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.96
- Translation Initiation · correlation 0.96
- SUMOylation & Splicing · correlation 0.93
- ER Protein Processing · correlation 0.92
- Oxidative Phosphorylation · correlation 0.91
- Epithelial Lipid Homeostasis · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.