Epithelial Lipid Homeostasis
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
EPCAM is the canonical epithelial cell adhesion marker. ECH1 encodes enoyl-CoA hydratase (fatty acid beta-oxidation), SCP2 is a sterol carrier/lipid transfer protein, PRDX6 is a peroxiredoxin with phospholipase activity, LAPTM4A is a lysosomal transmembrane protein, TMEM59 and TMEM98 are transmembrane proteins involved in membrane trafficking and epithelial differentiation. ITM2B is involved in amyloid processing and membrane homeostasis. The module is significantly downregulated in both UC and CD inflammation and recovers with remission, consistent with a general epithelial housekeeping/lipid homeostasis program. Neighbor context: co-expressed with OxPhos modules (M92, M39), suggesting shared dependence on metabolic homeostasis.
Genes
Most correlated modules
- TCA Cycle OxPhos · correlation 0.96
- Translation Initiation · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- Mitochondrial Complex I · correlation 0.93
- Oxidative Phosphorylation · correlation 0.92
- SUMOylation & Splicing · correlation 0.92
- ER Protein Processing · correlation 0.91
- ER Protein Folding · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.