Oxidative Phosphorylation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes UQCRH (Complex III subunit), COX6C, COX5A, COX4I1, COX7C (all Complex IV/cytochrome c oxidase subunits), UQCRB (Complex III), NDUFB11 (Complex I) are all mitochondrial respiratory chain components. EIF3K is a translation initiation factor (peripheral member), TXN encodes thioredoxin (redox homeostasis, mitochondria-associated). This module is a direct neighbor of M92 and represents the same OxPhos program with complementary subunit coverage. The two modules together capture the full electron transport chain across Complexes I, III, IV, and V.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Co-translational Chaperoning · correlation 0.96
- TCA Cycle OxPhos · correlation 0.94
- ER Protein Processing · correlation 0.94
- Translation Initiation · correlation 0.94
- Mitochondrial Membrane · correlation 0.93
- Mitochondrial Complex I · correlation 0.93
- SUMOylation & Splicing · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.