ER Protein Processing
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes POMP (proteasome maturation protein), SEM1 (proteasome regulatory subunit), and PSMB1 (proteasome beta subunit 1) anchor this module in proteasome biology. DAD1 is a subunit of the oligosaccharyltransferase complex (ER N-glycosylation) and anti-apoptotic. SEC61B (ER translocon beta subunit) and SPCS1 (signal peptidase complex subunit 1) are core ER protein translocation/processing components. NOP10 (H/ACA snoRNP, ribosome biogenesis), LAMTOR5 (Ragulator/mTOR lysosomal signaling), ATP6V0E1 (vacuolar H+-ATPase), ARPC3 (Arp2/3 actin nucleation), HSBP1 (heat shock factor binding), GTF3C6 (RNA Pol III). The dominant theme is ER protein processing and proteasomal degradation — classic protein quality control. All genes show core membership and uniform expression. Neighbor context: adjacent to M6 (neddylation/proteasome) and M74 (RNA processing), consistent with a protein biogenesis/quality control neighborhood.
Genes
Most correlated modules
- SUMOylation & Splicing · correlation 0.97
- Mitochondrial Complex I · correlation 0.95
- snRNP Splicing Complex · correlation 0.95
- snRNP RNA Processing · correlation 0.95
- ER Protein Folding · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- TCA Cycle OxPhos · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.